Haloperidol, Olanzapin, Risperidon ve Klozapinin Organ Banyosu Sistemi Kullanılarak Fare Detrusor Kası Üzerine Etkileri

Objective: The bladder normally shows no contractility or activity during the filling phase. In overactive urinary bladder, spontaneous contractions and detrusor instability are seen in phase incontinence occurs. This study aims to demonstrate effects of first-generation antipsychotic haloperidol second-generation antipsychotics olanzapine, risperidone, clozapine on mice isolated using organ bath system. Materials Methods: 63 male inbred were divided as saline, 0.125 mg/kg, 0.25 olanzapine 1 2 risperidone 0.5 1.25 mg/kg 2.5 groups. Mice treated with drugs for 21 days. Then, investigated isoproterenol-induced relaxation responses carbachol-induced strips. Results: We showed that relaxed by isoproterenol papaverine strips obtained from There significant differences KCl-induced contractile among groups.Conclusion: Olanzapine, increased relaxations muscle capacity. These might be clinically useful treatment patients should use drugs.